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Oncology in-vitro and in-vivo models

Cancer research is driven by robust in-vitro and preclinical models that transform drug discovery into successful clinical translation. At TheraIndx, we provide a comprehensive portfolio of in-vitro based assays and in-vivo models that can speed up your drug discovery pipeline with translational potential.

In-vitro models
  • Traditional 2D models: Ideal for high-throughput screening for cytotoxicity, cell-based assays, and mechanistic studies.
  • Advanced 3D models (spheroids, organoids, and hydrogel/matrix-embedded cultures): Mimics tumour architecture, cell-cell interactions and drug penetration.
In-vivo models
  • • Cell-line derived Xenograft (CDX model): Human cell lines implanted in immunocompromised mice to study tumour growth inhibition, drug screening and mechanistic studies
  • • Patient derived Xenograft (PDX model):Patient derived Xenograft (PDX model): Implantation of human patient cells, maintaining tumour heterogeneity and microenvironment
  • • Orthotopic model: Tumours implanted into the organ of origin to mimic tumour microenvironment and is of high clinical relevance
  • • Syngeneic model: Mice tumour cell lines implanted into genetically identical mice, valuable for studying immunotherapy
  • • Humanized model: Ideal for studying human specific cell therapies and in a controlled human-like immune environment.
Why partner with TheraIndx

TheraIndx offers a wide range of well-established cell lines, 3D models and in-house validated in-vivo models. We can customise/ establish new models of interest as per your request. TheraIndx offers the full drug discovery package: from in-vitro services to preclinical studies, involved at every stage until IND submission.

    References:
  • 1. Souto EP, Dobrolecki LE, Villanueva H, Sikora AG, Lewis MT. In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts. J Mammary Gland Biol Neoplasia. 2022 Jun;27(2): 10.1007/s10911-022-09520-y. Jun;27(2):23; PMCID: PMC9433358.

  • 2. Katt ME, Placone AL, Wong AD, Xu ZS, Searson PC. In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform. Front Bioeng Biotechnol. 2016 Feb 12;4:12. doi: 10.3389/fbioe.2016.00012. PMID: 26904541; PMCID: PMC4751256.

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